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  • 新聞詳情

    Trilink

    日期:2022-06-23 16:31
    瀏覽次數:1492
    摘要:Trilink是一家私有公司,總部位于美國加州圣地亞哥,生意遍布全球70余個國家和地區 TriLink BioTechnologies Nucleotide It is likely that among TriLink’s wide selection of modified nucleoside triphosphates (NTPs) you will find a compound to suit your application. We stock over 150 modified compounds, including Aminoallyl, Biotin and 2' Fluoro nucleotides.
    Trilink

    Trilink

      

    國別:美國Trilink

    成立于1999年的TriLink BioTechnologies是一家私有公司,總部位于美國加州圣地亞哥,生意遍布全球70余個國家和地區


    TriLink BioTechnologies  Nucleotides


    It is likely that among TriLink’s wide selection of modified nucleoside triphosphates (NTPs) you will find a compound to suit your application. We stock over 150 modified compounds, including Aminoallyl, Biotin and 2' Fluoro nucleotides. In addition, we offer specialty modified nucleotides such as bisphosphates, a series of monophosphates and CAP and mCAP. Whether your studies involve indirect DNA labeling, cDNA synthesis, nuclease resistance or a new application, we have the right modified NTP. Additionally, our nucleic acid chemists are experts in the synthesis of unique NTPs. Please inquire for larger quantities or specific concentrations.


    TriLink BioTechnologies  Custom Chemistry


    Our custom chemistry and contract research services include synthesis of unique phosphoramidites and polyphosphates, including mono-, di- and triphosphates, and other small molecules. If the small molecule your research requires is not commercially available, contact us. Collectively, our R&D team has decades of experience developing and optimizing nucleic acid synthesis schemes.



    TriLink BioTechnologies是世界上*專業核酸修飾和標記專家,其磚利的熱啟動DNTP和熱啟動引物是廣大診斷試劑開發商的啟明星,是高難度PCR(如高GC含量,長片段PCR,基因克隆)的又一把利器


    A New Approach to Early Phase Therapeutic GMP Manufacturing

    For over 20 years, we’ve been industry leaders synthesizing high quality research and diagnostic grade material, especially difficult and unusual constructs. Now we’re combining our expertise with a new state-of-the art GMP manufacturing facility to expand our services into mRNA and oligonucleotide therapeutics. 

    We offer single-batch or multiple-batch synthesis for IND-enabling tox studies and early phase clinical studies. With a wide variety of synthesis scales so that you can get just the amount of material you need for your particular study. Because we don’t require large scale synthesis, we can deliver your material quickly and at an affordable price. We provide drug substances plus supporting documentation to streamline the IND submission process and carry you through to clinical trials—saving you time and money.

    request-consult

    State-of-the-Art Facility 
    Our new, 2,000 square foot GMP facility is dedicated to manufacturing therapeutic products and is ISO certified by Lloyd’s Register. The controlled labs feature:
    • Validated ISO Class 7 and Class 8 clean rooms 
    • Compliance with ICH Q7, CFR 210 and other phase-appropriate GMPs
    • Single pass, HEPA filtered air system 
    • Routine monitoring for temperature, pressure, humidity and particle count 
    • Fully gowned staff
    • Facilities, processes, equipment and computerized systems are validated (IQ/OQ) and maintained in a validated state
    Available Products 
    Manufacturing of therapeutic grade material is available for: 
    • mRNA 
    • Long RNA 
    • Oligonucleotides 
    • Nucleotides & nucleosides 
    • Aptamers
    Getting Started with Therapeutic GMP Manufacturing
    To begin discussions and obtain a quote for your project, please send us a request. We’ll start with an intake meeting, where we’ll discuss your project, expectations and timelines. From there, we’ll work with you to determine the most effective and efficient process for your particular project. Although we may customize each project to meet your specific needs, the basic steps are outlined below. 

    • Information transfer
    • Technology transfer
    • Trial synthesis
    • Scale Up
    • Finalize process and documentation


    Gram Scale  

    Affordable Custom Synthesis
    Up to gram scales of mRNA and long RNA (multiple kilobases)

     

    Editing   Genome Editing & Manipulation Tools
    Zinc-finger nucleasesTALENSCRISPR and recombinases

     

    Gene Replacement  

    Gene Replacement, Immunotherapy & Delivery Optimization
    Featuring reporter gene mRNA, secreted factors like Factor IX and hAAT

     

    GMP  

    GMP Manufacturing
    Fully traceable from research to clinical grade

     

    Stem Cell   Reprogramming Factors
    mRNA for non-integrating generation of iPSCs

     

    Please contact us to discuss your path to pharmaceutical GMP manufacturing.



    CleanAmp? Hot Start PCR

    CleanAmp? Hot Start PCR is a patented technology developed under SBIR grants from the NIH. CleanAmp? Hot Start PCR products provide a specific, sensitive and flexible alternative to Hot Start DNA polymerases. TriLink has applied their expertise in modified nucleic acid chemistry to develop chemically modified dNTPs and primers that enable Hot Start PCR using standard Taq DNA polymerase. Simply swap out the standard dNTPs or primers in your PCR assay for the corresponding CleanAmp? product to create a Hot Start PCR reaction. CleanAmp? products are ideal for applications such as RT-PCR, multiplex PCR, digital PCR, fast PCR, end-point PCR and real-time PCR (including real-time RT-PCR and fast real-time PCR). CleanAmp? Hot Start PCR products offer: 

    ? Compatibility with all DNA polymerases and PCR applications 
    ? Unparalleled specificity and sensitivity due to significantly reduced non-specific amplification 
    ? Easy assay development with minimal optimization 
    ? Increased product yield 
    ? High amplification efficiency with short and long amplicons (up to 23kb) 
    ? Significant cost savings over other Hot Start technologies, including affordable licensing opportunities
    CleanAmp dNTP Specificity

    CleanAmp? dNTP Mix eliminates primer dimer formation.


    CleanAmp Primer Specificity

    CleanAmp? Primers improve PCR performance in systems prone to (A) primer dimer formation and (B) mis-priming.

    Activation of CleanAmp? Products occurs during the initial heat cycle of Hot Start PCR and each subsequent denaturation step, releasing just enough reagent to allow efficient amplification. By limiting the amount of active reagent during the early cycles when the target is in low concentration, CleanAmp? significantly reduces background amplification to achieve a reduction or even an elimination of primer dimer and mis-priming.

    CleanAmp dNTPs


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